Numerous lncRNAs that control theactivities of tumor cells may also have a major impact on trophoblasts,considering the parallels in proliferation, migration, and invasionbetween placental trophoblasts and tumor cells. This is especially noticeable in the pathways controllingcell cycle regulation, cellular invasion and migration, and angiogenesis. For example, lncRNA MALAT1 can suppress angiogenesis,cell cycle progression, apoptosis trophoblast development, migration,and invasion as well as recombinant hexokinase 2 (HK2) through itsinteraction with miR-216a-5p. Here, HK2 is linked to neoplasm.