PCNSL is predominantly classified as the ABC subtype, and ZEB2 has also been found to be enriched in ABC-DLBCL.36 In addition, MYD88 mutations, especially the hotspot L265P, are highly frequent in PCDLBCL-LT patients and systemic ABC-DLBCL.16,29,37 In our cohort, one patient had the L265P hotspot and another patient a non-L265P variant. This evidence concerns the gene MYD88 and primary central nervous system lymphoma.