In early‐stage CRC, six combinations were identified, including miR‐23a‐3p + miR‐150‐5p + CEA; miR‐92a‐3p + miR‐125a‐3p + miR‐150‐5p; miR‐92a‐3p + miR‐150‐5p + CEA; miR‐125a‐3p + miR‐150‐5p + CEA; miR‐23a‐3p + miR‐92a‐3p + miR‐150‐5p + CEA; and miR‐23a‐3p + miR‐125a‐3p + miR‐150‐5p + CEA. The gene discussed is CEACAM5; the disease is colorectal carcinoma.