Using blood plasma samples from 80 CRC patients across all stages and 20 healthy individuals, we identified four EV‐derived miRNA blood biomarkers (miR‐23a‐3p, miR‐92a‐3p, miR‐125a‐3p and miR‐150‐5p) by confirming statistical significance with relative quantification (RQ) values from real‐time PCR and integrated these with carcinoembryonic antigen (CEA) levels into an AI‐driven diagnostic model. Here, CEACAM5 is linked to colorectal carcinoma.