Findings did not materially change when further adjusted for lifestyle factors (HR per log10 decrease = 0.92, 95% CI = 0.85 to 0.99, P = .02) and dietary factors (HR = 0.92, 95% CI = 0.85 to 0.99, P = .03).The association of circulating ANGPTL4 concentrations with cancer risk did not differ by colorectal cancer subsite (HR colon cancer = 0.88, 95% CI = 0.81 to 0.96; HR rectal cancer = 0.97, 95% CI = 0.86 to 1.10; Phet = 0.20) and were consistent in lag analyses excluding participants within the first 2 and 5 years of follow-up (Figure 2A). This evidence concerns the gene ANGPTL4 and colonic neoplasm.