Nonetheless, the use of the E40K predicted loss-of-function variant, that has been shown to directly influence ANGPTL4 protein function, to proxy ANGPTL4 inhibition along with evidence that circulating ANGPTL4 and colorectal cancer risk share a causal variant within the ANGPTL4 locus should minimize the likelihood that these assumptions have been violated.51 Here, ANGPTL4 is linked to colorectal cancer.