HMOX1 and plasma cell myeloma: For instance, apoptotic vesicles from fibroblast-like cells inhibit ferroptosis and promote tissue survival via the KEAP1-NRF2 axis, while ethanolic extracts of Eclipta prostrata induce ferroptosis in multiple myeloma through the KEAP1-NRF2/HO-1 axis.29,30 Protein-protein interaction (PPI) network analysis further elucidated the interconnections among these differentially expressed proteins (Figure 5(d)).