In a study by Attalla et al., the upregulation of TIM-3 and TIGIT was linked to the suppression of NK cell effector function in patients with urothelial bladder carcinoma, and the overexpression of TIM-3 and TIGIT in peripheral blood NK cells may serve as biomarkers for assessing disease severity and monitoring treatment effectiveness [30]. The gene discussed is HAVCR2; the disease is bladder transitional cell carcinoma.