NFKB1 and intervertebral disk degenerative disorder: The main molecular pathways involved in senescence are p53-p21 CIP 1, p16 INK 4a, NF-κB, and MAPK, and the mechanisms involved in IDD include mechanical, oxidative, genotoxic, and inflammatory stress, as well as nutrient deprivation [[47], [48], [49], [50]].