Previous studies have demonstrated that electroacupuncture significantly upregulates the expression of colonic tyrosine kinase receptor (c-kit) and stem cell factor (SCF) in FC rats, increases the number of interstitial cells of Cajal (ICC), enhances their structure and function, regulates gastrointestinal motility, and induces a stimulating effect in the distal colon (Yao et al., 2022; Kuang et al., 2022). The gene discussed is KITLG; the disease is intrahepatic cholangiocarcinoma.