IGHE and Friedreich ataxia: Recent advances in our understanding of the immunopathogenesis of FA have highlighted the central role of IgE and its high-affinity receptor FcεRI, as well as mast cells and basophils, cytokines and chemokines, eosinophils, lipid mediators like leukotrienes and prostaglandins, and Th2 and B cells in mediating allergic responses.11