We believe that this systematic review and meta-analysis is the most robust investigation undertaken to date to support the use of biologics in IgE-mediated food allergy.26, 27, 28, 29, 30, 31 A key strength of our systematic review is the comprehensiveness of the search strategy across 10 international databases without geographical restrictions, contacting international experts in this field of research for unpublished, on-going or missing studies. Here, IGHE is linked to food allergy.