STAT3 and neoplasm: Promote the proliferation and migration of CRC cellsCdk5 up-regulation activates the Wnt / β-catenin signaling pathway and STAT3 pathwaysActivate TLR4 receptor and NF-κB signaling pathway, inhibit the expression of RASA1, activate RAS signaling pathway, induce s-phase accumulation, and enhance the proliferation of CRC cellsInhibition of immune response, inhibition of T cell activation and NK cell-induced killing of tumor cellsInflammation and chemokine expression fosters an inflammatory microenvironment, resulting in recurrent local inflammation, cell damage, and apoptosis.