NFKB1 and colorectal carcinoma: The other activates the RAS signaling pathway by activating the TLR4 receptor and NF-κB signaling pathway, leading to an increase in intracellular miR-21 and inhibiting the expression of RASA1, thereby inducing S-phase accumulation and enhancing the proliferation of CRC cells (Wang and Fang, 2023).