EIF2AK2 and viral infectious disease: Notably, in our analyses, we observed increased expression of previously described viral infection-related genes,22 including CXCL10, EIF2AK2, BIRC3, as well as antiviral genes and genes involved in pathogen response, such as IFIT1, IFIT2, ZC3HAV1, DDX3X (DDX3), SLFN5, TRIM25, NCOA7, SIX3, NT5C3A, and PAQR5 (Figure 2B).