Notably, in our analyses, we observed increased expression of previously described viral infection-related genes,22 including CXCL10, EIF2AK2, BIRC3, as well as antiviral genes and genes involved in pathogen response, such as IFIT1, IFIT2, ZC3HAV1, DDX3X (DDX3), SLFN5, TRIM25, NCOA7, SIX3, NT5C3A, and PAQR5 (Figure 2B). This evidence concerns the gene SIX3 and viral infectious disease.