In addition to AHSA1, other host genes of upregulated snoRNAs reported to be involved in general immune response98 might also impact viral infection and propagation, such as MATR3 (innate immune response), RFWD2 (induction of cell proliferation), or PHB2 (involved in RIG-1 mediated signal transduction) (see Table S16). The gene discussed is PHB2; the disease is viral infectious disease.