TNF and viral infectious disease: Pathways shared by these gene targets included alternative splicing (entire PPI network; Figure 3D), chromosomal rearrangement (red cluster), MECP2 signaling, virus infection pathways, tumor necrosis factor and interleukin-related pathways (orange cluster), as well as TGF-β signaling (green cluster), according to PPI and pathway analysis (Tables S7 and S8).