SLFN14 and Macrothrombocytopenia: Unlike the previously reported five mutations (K218E, K219E/N, V220D, and R223W), which are located in the N-terminal domain, this is the first mutation found in the C-terminal “helicase” domain of SLFN14. We investigated the structural characteristics and platelet properties associated with the T853fs mutation, and further explored the underlying pathways involved in macrothrombocytopenia.