Extensive review has been conducted on genetic variants, such as PTPN22, HLA-A2, HLA-B27, HLA DRB1*01, DRB1*08, DRB1*11, DRB1*13, DPB1*02, and DQB1*04, that contribute to JIA susceptibility (1, 108, 109). The gene discussed is PTPN22; the disease is juvenile idiopathic arthritis.