INS and type 2 diabetes mellitus: We found, for the first time to our knowledge, several insulin-mediated glucose hypo- and hypermetabolic clusters modulated by insulin in the brain of patients with Type 2 diabetes by SPM analysis that are associated with multiple brain functions.29-31 For instance, the hypometabolic clusters included right STG, left STG and right precuneus, all of which are found in the cortex region.