In the univariate regression analysis, we found that age, STB, DBIL, IBIL, eGFR, Scr, eGFR, BUN, 24h Urinary protein, UACR, hemoglobin, PLT, TC, TG, HDL-C, fibrinogen, Serum C4, ACEI/ARB, K-W nodules, renal tubular atrophy and renal interstitial inflammation were risk factors of DN progression (Table 2). This evidence concerns the gene C4A and liver dysplastic nodule.