ADSCs, in addition to their direct/indirect antitumor effects, have also demonstrated positive clinical effects in managing toxic side effects associated with chemoradiotherapy, including cisplatin-induced fertility impairment (81), salivary gland dysfunction following radiotherapy for head and neck tumors (resulting in xerostomia) (80, 82), and chemotherapy-induced granulocytopenia through secreting Granulocyte Colony-Stimulating Factor (G-CSF (83, 84). The gene discussed is CSF3; the disease is Decreased total granulocyte count.