ADSCs-mediated improvement of hyperglycemia may encompass islet β-cell regeneration via differentiation into insulin-producing cells or promotion of endogenous β-cell proliferation, modulation of hepatic metabolism toward enhanced glucose utilization, attenuation of chronic inflammation through anti-inflammatory cytokine secretion, and amelioration of insulin resistance (IR) in peripheral tissues via regulation of lipid homeostasis and insulin signaling pathways (12–15). This evidence concerns the gene INS and Insulin resistance.