ADSCs-mediated improvement of hyperglycemia may encompass islet β-cell regeneration via differentiation into insulin-producing cells or promotion of endogenous β-cell proliferation, modulation of hepatic metabolism toward enhanced glucose utilization, attenuation of chronic inflammation through anti-inflammatory cytokine secretion, and amelioration of insulin resistance (IR) in peripheral tissues via regulation of lipid homeostasis and insulin signaling pathways (12–15). This evidence concerns the gene INS and Hyperglycemia.