ERCC1 and neoplasm: Additionally, ERCC1 is inconsistently expressed with advancing tumor grade (grade 3 > grade 2 > grade 4 > grade 1), whereas ACTL6A shows significant overexpression with the grade of tumor progression (grade 4 > grade 3 > grade 2 > grade 1) (see Supplementary Table S1 and Supplementary Figure S1).