NFKB1 and Myocardial fibrosis: Tanshinone IIA exerts its cardioprotective effects in MIRI through various mechanisms, including scavenging ROS, inhibiting the NF-κB signaling pathway to reduce inflammation, regulating apoptosis-related proteins to prevent myocardial cell death, protecting mitochondrial function to mitigate oxidative stress, and preventing myocardial fibrosis to prevent additional damage to cardiac function (Zhu P.-C.