TLR4 and deep vein thrombosis: Platelet-derived HMGB1 facilitates monocyte migration and inhibits apoptosis through the RAGE/TLR4 axis (124), while disulfide HMGB1 from platelets mediates neutrophil recruitment and NET release via RAGE/TLR2 in experimental DVT, establishing a self-amplifying “thrombo-inflammatory loop” (125).