NCR3 and neoplasm: NKCEs have one targeting arm targeting tumor cell surface-specific antigens and the other targeting arm targeting activating receptors on the surface of NK cells, such as CD16a, NNKG2D (atural Killer Group 2 Member D), NKp30 (Natural Killer cell p30), etc., resulting in the formation of antigen-specific immune synapses between the NK cells and the tumor cells that which in turn triggers NK cell-mediated killing of tumor cells (194).