Focusing on genes differentially expressed in the T cell subsets, they found an overexpression of set of genes that control for cellular cytotoxicity, including GNLY, GZMA, GZMB, GZMH, GZMK, PRF1, CTSW, KLRB1, KLRD1, and NKG7. ALS patients exhibited greater levels of TCR expansions in cytotoxic CD4+ T cells as well as in CD4+ and CD8+ T cells with an activated phenotype (CCR7− CCL5+), compared with controls. The gene discussed is CCR7; the disease is amyotrophic lateral sclerosis.