While the Aβ cascade hypothesis has received the greatest attention (Kepp et al., 2023) Emerging theories such as tau pathology, neuroinflammation, and mitochondrial dysfunction further highlight the multifactorial nature of AD (Fig. 1) (Pérez et al., 2018, Tracy et al., 2022, Chen and Yu, 2023). Here, MAPT is linked to Alzheimer disease.