A previous study further identified an interaction between Lp(a) and BMI for first incident acute myocardial infarction on additive scale with RERI (95 % CI) of 2.45 (0.36, 4.54), but this additive interaction effect was only present at the fifth quintile of Lp(a) (> 246.9 mg/L) [52]. The gene discussed is LPA; the disease is myocardial infarction.