The results of other studies have shown more advanced pathological T stage, poor differentiation, and lymph node metastasis in cases with BIRC6 overexpression in NSCLC [ 28, 33] and esophageal squamous cell carcinomas [ 27, 29, 34], compared with those with low expression of BIRC6. This evidence concerns the gene BIRC6 and esophageal squamous cell carcinoma.