BIRC6 and metastatic malignant neoplasm in the lymph nodes: The results of other studies have shown more advanced pathological T stage, poor differentiation, and lymph node metastasis in cases with BIRC6 overexpression in NSCLC [ 28, 33] and esophageal squamous cell carcinomas [ 27, 29, 34], compared with those with low expression of BIRC6.