According to the traditional Chinese drug-disease target protein interaction network and core target bar chart, JUN, AKT1, MAPK1, RELA, IL6, MAPK14, MAPK8, ESR1, FOS, CXCL8 and EGFR might be the core genes that exert anti-lung cancer effect of cortex mori. This evidence concerns the gene EGFR and lung cancer.