TNF and diabetes mellitus: It mainly included the diabetes complications mediated by the AGE-RAGE pathway, atherosclerosis, hepatitis B, prostatic carcinoma, Kaposi sarcoma-associated herpes virus infection, IL-17 signaling pathway, bladder cancer, TNF signaling pathway, small cell lung cancer, HIF-1 signaling pathway, non-small cell lung cancer, etc., as shown in Table 3 and Figures 4B–6 shows the signaling pathways involved with non-small cell lung cancer and small cell lung cancer.