A number of studies have demonstrated abnormal activation of PI3K/AKT signaling in malignant tumors, which may have a bearing on the occurrence and development of tumors, regulates cell proliferation, survival, transformation, adhesion and extracellular matrix degradation, and participates in the whole process of tumors, such as liver cancer, pancreatic cancer and gastrointestinal tumors (30–32). Here, AKT1 is linked to liver cancer.