In this study, we developed a predictive model called a CSOARG (Cellular Senescence and Ovarian Aging-Related Genes) for the prognosis of ovarian cancer, which is related to cellular senescence and ovarian aging associated with therapeutical responses, and validated the effect of a hub gene WNK1 on ovarian cancer cell viability and migration. This evidence concerns the gene WNK1 and ovarian carcinoma.