SASP components directly amplify tumor proliferation and invasion: EREG/EGFR signaling activation via the MAPK/AKT axis mediates chemotherapy-induced progression in prostate cancer (70), while MMP1 and MMP3 degrade extracellular matrix (ECM) components to facilitate glioblastoma and lung cancer metastasis (71). The gene discussed is AKT1; the disease is neoplasm.