Fluorescence <i>in situ</i> hybridization did not detect a <i>TFE3</i> break, but RNA sequencing confirmed the presence of a <i>PRCC-TFE3</i> fusion.<h4>Conclusion</h4>The diagnosis of <i>TFE3</i>-RCC requires a comprehensive evaluation of histological features, immunohistochemical markers, and molecular testing. The gene discussed is PRCC; the disease is renal cell carcinoma.