It inhibits the activity of several receptor tyrosine kinases, including vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), fibroblast growth factor receptor (FGFR)-1, 2, 3 and proto-oncogene tyrosine-protein kinase receptor Ret (Ret), which can play a role in block tumor angiogenesis and reduce the nutrient supply to tumor cells, thereby inhibiting tumor proliferation and metastasis (27). The gene discussed is RET; the disease is neoplasm.