A rise in NT-proBNP ≥50% from baseline was associated with a 2.1-fold increased risk of arrhythmias (adjusted HR = 2.11, 95% CI 1.12–3.91, P = 0.015), while a ΔTroponin I ≥5 ng/L independently predicted arrhythmia occurrence (adjusted HR = 2.73, 95% CI 1.34–5.45, P = 0.005) (Table 3). The gene discussed is NPPB; the disease is Arrhythmia.