,79 Crucially, DN involves many factors that lead to injury (e.g., angiotensin-II, high glucose, TGF-β1),38 and these alternative injury models might help determine if the exacerbated injury in nephrin-Y3F mice was primarily related to mechanical strain or if these effects stem from the complex diabetic milieu. The gene discussed is TGFB1; the disease is liver dysplastic nodule.