CASR and Hypocalciuria: Notably, hypercalciuria occurs frequently in patients with autosomal dominant hypocalcemia caused by mutations in CaSR but is rare in those with Gα11 mutations; and conversely, patients with FHH and mice with inactivating Gα11 mutations have no alterations in urinary calcium excretion, compared to patients with inactivating CaSR mutations in which hypocalciuria is common.55