Notably, hypercalciuria occurs frequently in patients with autosomal dominant hypocalcemia caused by mutations in CaSR but is rare in those with Gα11 mutations; and conversely, patients with FHH and mice with inactivating Gα11 mutations have no alterations in urinary calcium excretion, compared to patients with inactivating CaSR mutations in which hypocalciuria is common.55 Here, CASR is linked to familial hypocalciuric hypercalcemia.