Galsulfase, indicated for Maroteaux-Lamy syndrome (MPS VI), addresses the deficiency of arylsulfatase B; laronidase, used for Hurler, Hurler-Scheie, and Scheie syndromes (MPS I), replaces the enzyme alpha-L-iduronidase [16]. Here, IDUA is linked to mucopolysaccharidosis type 6.