The search strategy incorporated keywords and Medical Subject Headings (MeSH) related to the population, such as "heart failure with preserved ejection fraction" and "HFpEF"; the intervention, including "empagliflozin" and "SGLT2 inhibitor"; and the outcomes, such as "cardiovascular mortality," "heart failure hospitalization," and "quality of life." To ensure a comprehensive search, reference lists of relevant reviews and included studies were also manually screened to identify any additional publications that may not have been captured in the initial database search. Here, SLC5A2 is linked to heart failure.