Comparing adult and pediatric GBM tumor profiles, FGFR3 gene alterations are only found in cases of adult GBM, including FGFR3-TACC3 gene fusions (2.4%) and FGFR3 K650E mutations (0.2%), while FGFR1 gene alterations, specifically FGFR1 K656E mutations, are ~ 7 times more frequent (2.2%) in pediatric glioma tumors compared to adult gliomas. This evidence concerns the gene FGFR1 and central nervous system cancer.