Prior studies have also shown that pediatric cancers such as rhabdomyosarcoma (RMS) harbor recurrent FGFR4 sequence variants and low-grade gliomas (LGG) harbor recurrent FGFR1/2 variants and fusions, including intragenic duplications in FGFR1 affecting the tyrosine kinase domain[8-10]. This evidence concerns the gene FGFR4 and childhood malignant neoplasm.