Using a broad search of all pediatric cancers, we observed the rates of alterations of the FGFR1, FGFR2, FGFR3, and FGFR4 genes in pediatric cancers to be 0.5%, 0.1%, 1.1%, and 0.8%, respectively. Here, FGFR3 is linked to childhood malignant neoplasm.