Despite the limited numbers of tumors with FGFR gene family alterations, however, high expression of the FGFR1, FGFR2, and FGFR3 genes in tumor samples were each associated with worse outcomes for children with neuroblastoma, with a trend toward worse outcomes in patients with high FGFR4 tumor expression as well [Figure 6A-D]. This evidence concerns the gene FGFR4 and neuroblastoma.