CD276 and acute myeloid leukemia: In one study, the human-mouse chimeric version of T-1A5 (ChT-1A5) inhibited the immunosuppressive function of B7 homolog 3 protein (B7-H3) and induced specific antibody-dependent cell-mediated cytotoxicity (ADCC) exclusively toward B7-H3+ AML cells in PDXs[144].