In PDXs with suboptimal response to cytarabine (Ara-C), the fraction of calcitonin receptor-like receptor-positive (CALCRL+) AML surged significantly following Ara-C treatment, and suppressing CALCRL expression markedly diminished the prevalence of LSCs, suggesting a link between CALCRL expression and drug resistance[25]. Here, CALCRL is linked to acute myeloid leukemia.