Additionally, PDX models engrafted with FLT3-ITD+ AML cells exhibit changes in vascular morphology, with a decrease in CD31+Sca-1high (Sca-1, stem cell antigen-1) endothelial cells and an increase in CD31+Sca-1low endothelial cells[63]. This evidence concerns the gene FLT3 and acute myeloid leukemia.