Identify key mutations closely associated with the initiation of AML, especially FLT3-ITD FLT3-ITD mutation is highly enriched in LICs but is relatively less prevalent in stem cells capable of reconstituting multilineage hematopoiesis FLT3 pathway inhibition remains an effective strategy for eliminating AML cells despite the presence of diverse coexisting mutations. The gene discussed is FLT3; the disease is acute myeloid leukemia.