Comparatively, in the mixed lineage leukemia-rearranged (MLL-r) B-ALL PDXs, neuron-glial antigen 2 (NG2) suppresses the expression of nuclear receptor subfamily 3 group C member 1 (NR3C1) that encodes the GC receptor, and this suppression occurs through the FLT3/AP-1 (activator protein 1) signaling axis[104]. The gene discussed is KMT2A; the disease is acute lymphoblastic leukemia.