Targeting cytosolic and mitochondrial proteins that prevent cell death, such as Bcl-2, Mcl-1, X-linked inhibitor of apoptosis protein (XIAP), and Aurora kinase B (AURKB), is one of the important ways to combat apoptosis resistance, as evidenced in AML and ALL PDXs[111,112]. This evidence concerns the gene AURKB and acute lymphoblastic leukemia.