In both the tumors formed by PC9-GR and HCC827-GR inoculation, the percentages of CD206+ TAMs in F4/80+ TAMs were highly upregulated, while the percentages of CD86+ TAMs in F4/80+ TAMs were downregulated, suggesting that EGFR-TKI-resistant NSCLC cells could induce M2 polarization and inhibit M1 polarization in CDX mouse models [Figure 1D and E]. The gene discussed is EGFR; the disease is non-small cell lung carcinoma.