NF-κB is a group of five transcription factors (p50, p52, p65, RelB, and c-Rel) that play a key role in immune response, inflammation, and cancer regulation, by controlling the expression of COX-2 as well as the synthesis of pro-inflammatory cytokines (IL-6, IL-8 and TNF-α) (Figure 3) [40,45]. The gene discussed is NFKB1; the disease is cancer.