Fluorinated flavonoids exhibit anti-inflammatory properties by reducing lymphocyte viability and inhibiting nitric oxide production [93,129].Due to the ability of fluorinated chalcone derivatives to cross the BBB and their strong binding to β-amyloid (Aβ) plaques, they are promising candidates for neurodegenerative disease imaging [87].Fluorination of hydroxyl-containing flavonoids enhances their antioxidant properties [88]. The gene discussed is PPIB; the disease is neurodegenerative disease.