This study aims to address this gap by investigating the interactions between key receptor targets implicated in sepsis pathophysiology—namely TLR4 (innate immunity), IRAK-1 (inflammation), and caspase-3 (apoptosis)—and several NAOs ligands: curcumin, chlorogenic acid, EGCG, resveratrol, and quercetin. The gene discussed is TLR4; the disease is Sepsis.