SFN, a key isothiocyanate derived from broccoli, has garnered significant attention for its health-promoting properties: anticancer activity against various types of cancer, including prostate, pancreatic, leukemia, and colon cancer; enhancing the body’s antioxidant defenses by activating the Nrf2 pathway and NF-κB inhibition. This evidence concerns the gene NFKB1 and malignant colon neoplasm.