HSPA8 and Parkinson disease: Supporting evidence for the involvement of impaired proteostasis in PD pathogenesis comes from the observation of increased expression of autophagosomes, decreased expression of lysosomal marker proteins, and proteins of chaperone-mediated autophagy (lysosomal-associated membrane protein 2A (LAMP2A) and HSC70) in postmortem analysis of PD patients’ brains [39,40,41].