SELPLG and Sepsis: For example, while the binding of platelet P-selectin to the neutrophil receptor, P-selectin glycoprotein ligand-1 (PSGL1), is crucial for NETosis in murine sepsis models, human neutrophils, on the other hand, require firm adhesion mediated via neutrophil integrins and platelet glycoprotein 1bα [55,56,57].