Tripartite motif-containing protein 67 (TRIM67), an E3 ubiquitin ligase of the TRIM family, orchestrates DLK1 (delta-like non-canonical Notch ligand 1) ubiquitination via its RING domain, thereby activating Notch signaling to drive NSCLC (non-small cell lung cancer) proliferation. The gene discussed is TRIM67; the disease is non-small cell lung carcinoma.