In this study, we observed that the circulating levels of IL-6, IL-10, and TNF-α were significantly different between COVID-19 pneumonia and non-COVID-19 pneumonia patients at admission; both IL-6 and IL-10 levels were found to be increased in the critical COVID-19 group while the TNF-α levels was found to be decreased. The gene discussed is IL10; the disease is COVID-19.