Moreover, natural resistance-associated macrophage protein OsNRAMP1 and ethylene-responsive transcription factor OsERF48 are also significantly upregulated under both heat and BPH stress, whereas genes such as abscisic acid-stress-ripening-inducible 1 protein OsASR5, glutamine synthetase OsGS1 and WINDHOSE protein OsWIH2 are significantly downregulated by the two-stress combination. The gene discussed is GLUL; the disease is benign prostatic hyperplasia.