The transcript levels of JA biosynthesis and signaling genes OsLOX1 (lipoxygenase 1), OsAOS1 (allene oxide synthase 1) and OsJAZ11 (jasmonate-zim domain 11) were significantly depressed in eds1 and pad4 plants in the absence of BPH. The gene discussed is PADI4; the disease is benign prostatic hyperplasia.