Activation of the NLRP3 inflammasome can be triggered by metabolic danger signals, such as cholesterol crystals (related to atherosclerosis), uric acid crystals (associated with gout), fatty acids (linked to diabetes), and aging-related factors like aggregated and misfolded proteins, including fibrillar amyloid-β (in Alzheimer’s disease) and α-synuclein (in Parkinson’s disease) [9]. The gene discussed is NLRP3; the disease is gout.