NQO1 and Alzheimer disease: As reported by Gladen-Skolarsky et al., administration of an aqueous extract of W. somnifera in transgenic mice mimicking AD determined the upregulation of the genes Nrf2 and NAD(P)H quinone oxidoreductase 1 (NQO1) in the cortex of mouse brain, along with the concomitant reduction in Aβ plaque deposition in the hippocampus and improvements in cognitive, behavioral, and psychological symptoms [46].