TP53 and cancer: These effects are mediated through multiple molecular mechanisms that target key pathways involved in cancer cell proliferation, survival, metastasis, and angiogenesis [14], influencing several transcription factors involved in cancer aggressiveness and progression such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), nuclear factor erythroid 2–related factor 2 (Nrf2), and p53 [9,13].