SERPINE1 and endothelial dysfunction: Additionally, one of the major anti-fibrinolytic factors, plasminogen activator inhibitor-1 (PAI-1), was shown to be highly involved in radiation-induced endothelial dysfunction and the ensuing prothrombotic state; in fact, abrogating the function of PAI-1 in endothelial cells has been proven to significantly reduce radiation-induced cell death [62,63].